SPT-IN-1

CAT: 0804-HY-125351-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-125351-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

CAS Number

1933533-18-6

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/spt-in-1.html

Purity

99.18

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(CC(O)=O)C=C3)=C1)=O

Molecular Formula

C22H24N2O3

Molecular Weight

364.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Genin MJ, et al. Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem. 2016;59 (12) :5904-5910.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

SPT Imidazopyridine 1

CAS Number	1933533-18-6
PubChem CID	131954583
IUPAC Name	2-[4-(6-heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid
Molecular Formula	C22H24N2O3
Molecular Weight	364.4
XLogP	5
Topological Polar Surface Area	71.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Heavy Atom Count	27
Formal Charge	0
Complexity	502

SMILES

CCCCCCC(=O)C1=CN2C=CN=C2C(=C1)C3=CC=C(C=C3)CC(=O)O

InChI

InChI=1S/C22H24N2O3/c1-2-3-4-5-6-20(25)18-14-19(22-23-11-12-24(22)15-18)17-9-7-16(8-10-17)13-21(26)27/h7-12,14-15H,2-6,13H2,1H3,(H,26,27)

InChIKey

MMYRYMMKMUTPBB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1933533-18-6

CID: 131954583

Formula: C22H24N2O3

MW: 364.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	364.4
XLogP3	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	364.17869263
Monoisotopic Mass	364.17869263
Topological Polar Surface Area	71.7 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	502
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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