FIDAS-3

CAT: 0804-HY-136145-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-136145-01Size:5 mg

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Description

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A) . FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

CAS Number

1266684-01-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fidas-3.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1

Molecular Formula

C16H15F2N

Molecular Weight

259.29

Precautions

H302, H315, H319

References & Citations

[1]Zhang W, et al. Fluorinated N, N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8 (4) :796-803.|[2]Zhang W, et al. Fluorinated N, N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54 (5) :1288-97.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Fidas-3

CAS Number	1266684-01-8
PubChem CID	51039205
IUPAC Name	4-[(E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethylaniline
Molecular Formula	C16H15F2N
Molecular Weight	259.29
XLogP	4.5
Topological Polar Surface Area	3.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	19
Formal Charge	0
Complexity	285

SMILES

CN(C)C1=CC=C(C=C1)/C=C/C2=C(C=CC=C2F)F

InChI

InChI=1S/C16H15F2N/c1-19(2)13-9-6-12(7-10-13)8-11-14-15(17)4-3-5-16(14)18/h3-11H,1-2H3/b11-8+

InChIKey

YBJDCOLXJYDHOM-DHZHZOJOSA-N

Chemical Structure

2D Structure

CAS: 1266684-01-8

CID: 51039205

Formula: C16H15F2N

MW: 259.29

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	259.29
XLogP3	4.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	259.11725581
Monoisotopic Mass	259.11725581
Topological Polar Surface Area	3.2 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	285
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
RAC68401-01	FIDAS-3
BA4942-50	FIDAS-5

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