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Valinomycin

CAT: 0804-HY-N6693-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6693-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Valinomycin is a potassium-specific ionophore, the valinomycin-K+ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K+ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research[1][2].
CAS Number
2001-95-8
Product Name Alternative
NSC 122023
UNSPSC
12352209
Hazard Statement
H300, H310
Target
Antibiotic; Apoptosis; Autophagy; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy
Field of Research
Cancer; Infection; Others
Assay Protocol
https://www.medchemexpress.com/valinomycin.html
Purity
99.29
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
CC([C@@H](O1)C(N[C@](C(O[C@H](C(N[C@H](C(O[C@@H](C(N[C@@H](C(O[C@](C)([H])C(N[C@@H](C(C)C)C(O[C@H](C(C)C)C(N[C@H](C(C)C)C(O[C@@H](C)C(N[C@](C(C)C)([H])C1=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)C)=O)([H])C(C)C)=O)C
Molecular Formula
C54H90N6O18
Molecular Weight
1111.32
Precautions
H300, H310
References & Citations
[1]Huang S, et al. The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis. Microorganisms. 2021, 9 (4) :780.|[2]Zhang QW, et al. RETRACTED: Liposomal valinomycin mediated cellular K+ leak promoting apoptosis of liver cancer cells. J Control Release. 2021, 337:317-328.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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