Validamycin A (Standard)

• Description:

  Validamycin A (Standard) is the analytical standard of Validamycin A. This product is intended for research and analytical applications. Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Fungal; Reference Standards; Tyrosinase

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease; Others

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/validamycin-a-standard.html

• Smiles:

  O[C@H]1[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)C[C@H](CO)[C@@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]1O

• Molecular Formula:

  C20H35NO13

• Molecular Weight:

  497.49

• References & Citations:

  [1]Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.|[2]Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.|[3]N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo) . 1987 Apr;40 (4) :526-32.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [37248-47-8]