Validamycin A
CAT:
804-HY-B0856-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Validamycin A
- CAS Number: 37248-47-8
- UNSPSC Description: Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3].
- Target Antigen: Antibiotic; Fungal; Tyrosinase
- Type: Natural Products
- Related Pathways: Anti-infection;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/validamycin-a.html
- Purity: 60.0
- Solubility: H2O : 125 mg/mL (ultrasonic)
- Smiles: O[C@H]1[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)C[C@H](CO)[C@@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]1O
- Molecular Weight: 497.49
- References & Citations: [1]Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.|[2]Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.|[3]N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo). 1987 Apr;40(4):526-32.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light, stored under nitrogen)
- Clinical Information: No Development Reported