Validamycin A

CAT: 0804-HY-B0856-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0856-01Size:100 mg
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Description
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3].
CAS Number
[37248-47-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Fungal; Tyrosinase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/validamycin-a.html
Concentration
10mM
Purity
60.0
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)C[C@H](CO)[C@@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]1O
Molecular Formula
C20H35NO13
Molecular Weight
497.49
Precautions
H315, H319, H335
References & Citations
[1]Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.|[2]Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.|[3]N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo) . 1987 Apr;40 (4) :526-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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