ddATP (trisodium)

ddATP (trisodium)

• Product Name Alternative: 2',3'-Dideoxyadenosine 5'-triphosphate (trisodium)
• CAS Number: 72029-21-1
• UNSPSC Description: ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection[1][2][4].
• Target Antigen: DNA/RNA Synthesis; HIV
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/ddatp-trisodium.html
• Purity: 98.0
• Solubility: 10 mM in H2O
• Smiles: NC1=NC=NC2=C1N=CN2[C@H](O3)CC[C@H]3COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
• Molecular Weight: 541.13
• References & Citations: [1]van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. |[2]Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. |[3]Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218(2):iyab054. |[4]C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. |[5]Hao Z, et al. Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34(4):431-5.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, 2 years
• Clinical Information: No Development Reported