INT-777 (R-enantiomer)

INT-777 (R-enantiomer)

• CAS Number: 9007-83-4
• UNSPSC Description: INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
• Target Antigen: G protein-coupled Bile Acid Receptor 1
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/INT-777-R-enantiomer.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1
• Molecular Weight: 450.65
• References & Citations: [1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported