INT-777 (R-enantiomer)

• UNSPSC Description:

  INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

• Target Antigen:

  G protein-coupled Bile Acid Receptor 1

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/INT-777-R-enantiomer.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1

• Molecular Weight:

  450.65

• References & Citations:

  [1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4