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Alvimopan (dihydrate)

CAT: 0804-HY-76657A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-76657A-01Size:5 mg
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Description
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively) . Alvimopan dihydrate can be used for the research of postoperative ileus[1][2][3].
CAS Number
170098-38-1
Product Name Alternative
ADL 8-2698 dihydrate; LY 246736 dihydrate
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/alvimopan-dihydrate.html
Concentration
10mM
Purity
98.66
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=CC=CC([C@@]2(C)[C@@H](C)CN(C[C@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)CC2)=C1.O.O
Molecular Formula
C25H36N2O6
Molecular Weight
460.56
Precautions
H302, H312, H332
References & Citations
[1]Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4- (3-hydroxyphenyl) piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2006-12.|[2]Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33 (10) :574-83.|[3]Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
μ Opioid Receptor/MOR

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