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Alvimopan

CAT: 0804-HY-13243-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13243-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively) . Alvimopan can be used for the research of postoperative ileus[1][2][3].
CAS Number
156053-89-3
Product Name Alternative
ADL 8-2698; LY 246736
UNSPSC
12352005
Hazard Statement
H315, H319, H400
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/alvimopan.html
Purity
98.66
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(CNC([C@@H](CC1=CC=CC=C1)CN2C[C@@H]([C@](C3=CC=CC(O)=C3)(CC2)C)C)=O)O
Molecular Formula
C25H32N2O4
Molecular Weight
424.53
Precautions
H315, H319, H400
References & Citations
[1]Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4- (3-hydroxyphenyl) piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2006-12.|[2]Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33 (10) :574-83.|[3]Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
μ Opioid Receptor/MOR

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CatalogName
A3162-50Alvimopan

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