IMM-01

• Description :

  IMM-01 is a mammalian Diaphanous (mDia) -related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Ras

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/imm-01.html

• Purity :

  99.87

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=C(/C=N/NC(NC(C)(C)C)=S)C(O)=C1

• Molecular Formula :

  C12H17N3O2S

• Molecular Weight :

  267.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]L Leanne Lash, et al. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73 (22) :6793-803.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• CAS Number :

  [218795-74-5]