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Nalidixic Acid-d5

CAT: 0804-HY-B0398S-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0398S-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
CAS Number
1189467-36-4
UNSPSC
12352005
Hazard Statement
H302-H317-H334
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
C(C([2H])([2H])[2H])(N1C=2C(C(=O)C(C(O)=O)=C1)=CC=C(C)N2)([2H])[2H]
Molecular Formula
C12H7D5N2O3
Molecular Weight
237.27
Precautions
P261-P264-P270-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp.|[3]Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported