CP-640186 (hydrochloride)

• UNSPSC Description:

  CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation[1][2].

• Target Antigen:

  Acetyl-CoA Carboxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/CP-640186-hydrochloride.html

• Solubility:

  DMSO : ≥ 48 mg/mL|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C([C@H]1CN(C2CCN(C(C3=C(C=CC=C4)C4=CC5=C3C=CC=C5)=O)CC2)CCC1)N6CCOCC6.Cl

• Molecular Weight:

  522.08

• References & Citations:

  [1]Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.|[2]Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.|[3]Daniel Hess, et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010 Jun 30;5(6):e11394.J Exp Med. 2021 Dec 6;218(12):e20210639.|Am J Transl Res. 2019 Nov 15;11(11):7104-7114.|bioRxiv. 2024 May 25.|Department of Microbiology & Immunology. Seoul National University Graduate School. 2015 Aug. |Front Oncol. 2021 Apr 22;11:665763.|Front Oncol. 2021 Apr 6.|Nat Commun. 2024 Oct 21;15(1):9062.|Nutrients. 2021 May 21;13(6):1740.|Viruses. 2019 Dec 10;11(12):1145.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  591778-70-0