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ZQ-16

CAT: 0804-HY-124571-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124571-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120[1].
CAS Number
376616-73-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
GPR84
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zq-16.html
Purity
99.0
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(SCCCCCC)=NC(O)=C1
Molecular Formula
C10H16N2O2S
Molecular Weight
228.31
Precautions
H315, H319, H335
References & Citations
[1]Qing Zhang, et al. Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther. 2016 May;357 (2) :337-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-(Hexylthio)pyrimidine-4,6-diol

a GPR84 agonist; structure in first source

CAS Number376616-73-8
PubChem CID1912564
IUPAC Name2-hexylsulfanyl-4-hydroxy-1H-pyrimidin-6-one
Molecular FormulaC10H16N2O2S
Molecular Weight228.31
XLogP2.4
Topological Polar Surface Area87
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count15
Formal Charge0
Complexity287
SMILES
CCCCCCSC1=NC(=CC(=O)N1)O
InChI
InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)
InChIKey
UYXOAKRMLQKLQX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(Hexylthio)pyrimidine-4,6-diol
CAS: 376616-73-8
CID: 1912564
Formula: C10H16N2O2S
MW: 228.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight228.31
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass228.09324893
Monoisotopic Mass228.09324893
Topological Polar Surface Area87 Ų
Heavy Atom Count15
Formal Charge0
Complexity287
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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