UAA crosslinker 1

CAT: 0804-HY-111434-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-111434-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases[1]. UAA crosslinker 1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

1167421-25-1

UNSPSC

12352211

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/UAA_crosslinker_1.html

Purity

98.0

Solubility

DMSO : 2.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@@H](CCCCNC(OCCN=[N+]=[N-])=O)C(O)=O

Molecular Formula

C9H17N5O4

Molecular Weight

259.26

References & Citations

[1]VanBrunt MP, et al. Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry. Bioconjug Chem. 2015 Nov 18;26 (11) :2249-60.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

(2S)-2-amino-6-{[(2-azidoethoxy)carbonyl]amino}hexanoic acid

N6-((2-azidoethoxy)carbonyl)-L-lysine is an organic molecular entity.

CAS Number	1167421-25-1
PubChem CID	49842364
IUPAC Name	(2S)-2-amino-6-(2-azidoethoxycarbonylamino)hexanoic acid
Molecular Formula	C9H17N5O4
Molecular Weight	259.26
XLogP	-1.7
Topological Polar Surface Area	116
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Heavy Atom Count	18
Formal Charge	0
Complexity	316

SMILES

C(CCNC(=O)OCCN=[N+]=[N-])C[C@@H](C(=O)O)N

InChI

InChI=1S/C9H17N5O4/c10-7(8(15)16)3-1-2-4-12-9(17)18-6-5-13-14-11/h7H,1-6,10H2,(H,12,17)(H,15,16)/t7-/m0/s1

InChIKey

RPLCQQYRZLXMKL-ZETCQYMHSA-N

Chemical Structure

2D Structure

CAS: 1167421-25-1

CID: 49842364

Formula: C9H17N5O4

MW: 259.26

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	259.26
XLogP3	-1.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Exact Mass	259.12805404
Monoisotopic Mass	259.12805404
Topological Polar Surface Area	116 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	316
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-144333	DNA crosslinker 1 (dihydrochloride)
HY-130547A	BS2G Crosslinker
HY-114697-01	DSG Crosslinker
HY-126349	DTSSP Crosslinker
HY-124329-01	BS3 Crosslinker
HY-120937-01	DC4 Crosslinker
HY-W011541-01	SIA Crosslinker
HY-124318-01	SMPH Crosslinker
HY-118759-01	DSP Crosslinker
HY-114697S	DSG Crosslinker-d4

Alternative Products

Catalog	Name
610311	SMCC crosslinker
571612	SPDP Crosslinker
571623	DST Crosslinker
571628	DCC Crosslinker
571601	BMPS Crosslinker
T15175-01	DSP Crosslinker
T19941-01	MBS Crosslinker
T16903-01	SMPH Crosslinker
T14833-01	BS3 Crosslinker
E1666	Ultraviolet crosslinker

UAA crosslinker 1

Chemical Information

Related Products

Alternative Products

Popular Products