G-744

• Description:

  G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].

• UNSPSC:

  12352005

• Target:

  Btk

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/G-744.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(C1=O)C=C(C2=CC=CC(N3C(C(SC4=C5CC(C)(C)C4)=C5CC3)=O)=C2CO)C=C1NC6=CC=NC=N6

• Molecular Formula:

  C29H29N5O3S

• Molecular Weight:

  527.64

• References & Citations:

  [1]Wang X, et al. Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. ACS Med Chem Lett. 2017 May 3;8 (6) :608-613.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1346669-54-2]