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Meldonium (dihydrate)

CAT: 0804-HY-B1836A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1836A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2) . Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor[1][2].
CAS Number
86426-17-7
Product Name Alternative
MET-88 (dihydrate) ; Quaterin (dihydrate)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/meldonium-dihydrate.html
Purity
99.0
Solubility
DMSO : 4.85 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
C[N+](C)(C)NCCC([O-])=O.O.O
Molecular Formula
C6H18N2O4
Molecular Weight
182.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113 (Pt B) :771-780.|[2]Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51 (1) :22-25.|[3]Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
J Pharm Biomed Anal. 2021 Feb 20:195:113870.|J Anim Sci. 2022 Apr 1;100 (4) :skac069.|Nat Commun. 2025 Feb 11;16 (1) :1543.

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