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20-SOLA

CAT: 0804-HY-160186-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160186-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
20-SOLA is an orally active 20-HETE antagonist. 20-SOLA greatly ameliorates changes in blood pressure and renal injury associated with a Streptozotocin (STZ) -diabetic mouse model. 20-SOLA facilitates the restoration of coronary collateral growth (CCG) after ischemic injury. 20-SOLA can be studied for research in cardiovascular diseases and diabetes[1].
UNSPSC
12352211
Target
Cytochrome P450; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/20-sola.html
Purity
98.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COCCOCCOCCOCCOCCOCCOC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O
Molecular Formula
C33H62O9
Molecular Weight
602.84
References & Citations
[1]Pascale JV, et al. 20-Hydroxyeicosatetraenoic acid (20-HETE) : Bioactions, receptors, vascular function, cardiometabolic disease and beyond. Adv Pharmacol. 2023;97:229-255.|[2]Gilani, A., et al., (2021) . 20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance. Prostaglandins & other lipid mediators, 152, 106485. |[3]Gilani, A., et al., (2018) . High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE. American journal of physiology. Regulatory, integrative and comparative physiology, 315 (5), R934–R944.|[4]Gangadhariah, M. H., et al., (2015) . Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Journal of the American Society of Nephrology: JASN, 26 (3), 597–610.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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