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Wnt-5a

CAT: 0209-103-PA16Size: 200 µgDry Ice: NoHazardous: No
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CAT#:0209-103-PA16Size:200 µg
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Description
Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to transform cells or signal through the canonical beta-catenin pathway that is so important in cancer, particularly colorectal cancer. Recent work in a wide range of human tumours has pointed to a critical role for Wnt-5a in malignant progression, but there is conflicting evidence whether Wnt-5a has a tumour-promoting or -suppressing role. Emerging evidence suggests that the functions of Wnt-5a can be drastically altered depending on the availability of key receptors. Hence, the presence or absence of these receptors may go some way to explain the conflicting role of Wnt-5a in different cancers.
Synonyms
Wnt-5a; Wnt5a; Wnt 5a; Wnt
NCBI Gene ID
22418
UniProt
P22725
Accession Number
NP_033550.2
Accession Number mRNA
NM_009524.3
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse Wnt-5a
Clone
Rabbit IgG
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized
Reconstitution
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

UniProtKB · P22725

Protein Wnt-5a

WNT5A_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P22725
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Wnt5a
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q8BM17, Q8BMF9, Q8VCV6
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ChondrogenesisDifferentiationWnt signaling pathway

Molecular function

Developmental protein

Technical term

Direct protein sequencingReference proteome

PTM

Disulfide bondGlycoproteinLipoprotein

Cellular component

Extracellular matrixSecreted

Domain

Signal

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