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Wnt-3a

CAT: 0209-M30-231SSize: 10 µgDry Ice: NoHazardous: No
CAT#:0209-M30-231SSize:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS) . Wnt-3a signaling is essential for various morphogenetic events, including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid-modified, cysteine-rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway, Wnt family members bind to and activate, seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant Murine Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues.
Synonyms
Wingless-type MMTV (mouse mammary tumor virus) integration site family member 3a
NCBI Gene ID
22416
UniProt
P27467
Accession Number
NP_033548.1
Accession Number mRNA
NM_009522.2
Reactivity
Mouse
Cross Reactivity
Mouse
Label
His-Tag
Sequence
MSYPIWWSLA VGPQYSSLST QPILCASIPG LVPKQLRFCR NYVEIMPSVA EGVKAGIQEC QHQFRGRRWN CTTVSNSLAI FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGSAAICG CSSRLQGSPG EGWKWGGCSE DIEFGGMVSR EFADARENRP DARSAMNRHN NEAGRQAIAS HMHLKCKCHG LSGSCEVKTC WWSQPDFRTI GDFLKDKYDS ASEMVVEKHR ESRGWVETLR PRYTYFKVPT ERDLVYYEAS PNFCEPNPET GSFGTRDRTC NVSSHGIDGC DLLCCGRGHN ARTERRREKC HCVFHWCCYV SCQECTRVYD VHTCKLEHHH HHH
Purity
> 85% by SDS-PAGE & Coomassie Stain
Length
343
Form
Lyophilized
Host or Source
E. coli
N Terminal Sequence
SYPIW

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