VEGFR-2/KDR

CAT: 0209-101-M22Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M22Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs) . All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Synonyms
Vascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; VEGFR2; kinase insert domain protein receptor
NCBI Gene ID
3791
UniProt
P35968
Accession Number
NP_002244.1
Accession Number mRNA
NM_002253.2
Chromosomal Location
4q11-q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human soluble extracellular KDR (D7)
Clone
(#EWC)
Applications
ELISA, WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
ELISA: Use at 1-10 µg/ml. Western blotting: Use at 2-5 µg/ml. FACS analysis: Use at 5 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Notes
The antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of different human cell types.
Host or Source
Mouse
Isotype
IgG1

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