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VCAM-1

CAT: 0209-103-M98Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M98Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.
Synonyms
CD106; Vascular Cell Adhesion Protein 1; V-CAM 1
NCBI Gene ID
22329
UniProt
P29533
Accession Number
NP_035823.3
Accession Number mRNA
NM_011693.3
Chromosomal Location
3 G1; 3 50.8 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Cytokine stimulated mouse endothelial cells
Clone
(#MAB0804)
Applications
WB, IHC (P), IP
Purification Method
Protein A/G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:100-1000; IHC (P) : 1:25-100
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS (sterile)
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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