RANTES (CCL 5)

• Description :

  RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant murine RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms :

  Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes

• NCBI Gene ID :

  20304

• UniProt :

  P30882

• Accession Number :

  NP_038681.2

• Accession Number mRNA :

  NM_013653.3

• Chromosomal Location :

  11 C; 11 47.4 cM

• Reactivity :

  Mouse

• Cross Reactivity :

  Rat, Mouse, Leech, Human, Bacteria

• Sequence :

  SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract total human lymphocyte population and total murine T cell population using a concentration range of 1.0-10.0 ng/ml.

• Length :

  68

• Form :

  Lyophilized

• Molecular Weight :

  7.8 kDa

• Host or Source :

  E. coli