Podoplanin, soluble

CAT: 0209-S01-R46Size: 5 µgDry Ice: NoHazardous: No
CAT#:0209-S01-R46Size:5 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2) . Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
Synonyms
Pdpn; E11; Gp38; OTS-8; RTI40; T1-alpha
NCBI Gene ID
54320
UniProt
Q64294
Accession Number
NP_062231.1
Accession Number mRNA
NM_019358.1
Chromosomal Location
5q36
Reactivity
Rat
Cross Reactivity
Rat
Label
His-Tag
Sequence
GAIGALEDDLVTPGPGDDMVNPGLEDRIETTDTTGELDKSTAKAPLVPTQPPIEELPTSGTSDHDHKEHESTTTVKAVTSHSTDKKTTHPNRDNAGGETQTTDKKDGLAVVTLEHHHHHH
Assay Protocol
We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Purity
> 98% by SDS-PAGE
Bioactivity
Testing in progress.
Length
120
Form
Lyophilized
Buffer
0.5X PBS
Reconstitution
Water
Storage Conditions
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted sPodoplanin should be stored in working aliquots at -20°C.
Host or Source
E. coli
N Terminal Sequence
GAIGALED

Related Products

CatalogName
102-PA40AGPodoplanin
102-PA40SPodoplanin
101-MBi40Podoplanin
104-M40Podoplanin
101-M40Podoplanin
103-PA40SPodoplanin
103-M40Podoplanin
103-PA40Podoplanin
101-M41Podoplanin
103-MBi40Podoplanin

Alternative Products

CatalogName
MBS691538-01Human Podoplanin, soluble
MBS691731-01Mouse Podoplanin, soluble
MBS692151-01Rat Podoplanin, soluble
AP79286-01Podoplanin

Popular Products