Neurturin Recombinant Protein
CAT:
209-100-083
Size:
20 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Neurturin Recombinant Protein
- Description: Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR α (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
- Synonyms: NRTN; NTN
- CAS Number: 9000-83-3
- NCBI Gene ID: 4902
- UniProt: Q99748
- Accession Number: NP_004549.1
- Accession Number mRNA: NM_004558.3.
- Gene Location: 19p13.3
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Mouse, Rat, Human
- Sequence: ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV
- Detection Range: Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analysis
- Length: 204
- Form: Lyophilized
- Molecular Weight: 11.8 kDa
- Shipping Conditions: Room Temperature