MMP-24

• Description:

  Matrix metalloproteinase-24 or MT5-MMP is an enzyme that in humans and mouse is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP-2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.

• Synonyms:

  Mmp24; MT5MMP; MTMMP5; MT5-MMP; AU040325

• NCBI Gene ID:

  17391

• UniProt:

  Q9R0S2

• Accession Number:

  NP_034938.3

• Accession Number mRNA:

  NM_010808.3

• Chromosomal Location:

  2 H1; 2 87.5 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Mouse recombinant protein of MMP-24 Catalytic Domain

• Clone:

  (#7J71)

• Applications:

  WB

• Purification Method:

  Protein A/G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2