Products for Research Use Only
RegisterLogin

MMP-8

CAT: 0209-101-M112Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-101-M112Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNFα and GM-CSF. MMP8 is capable of cleaving types I, II and III triplehelical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, βcasein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP8 consists of several domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexinlike domain. MMP8 is heavily glycosylated.
Synonyms
MMP8; HNC; CLG1; MMP-8; PMNL-CL
NCBI Gene ID
4317
UniProt
P22894
Accession Number
NP_002415.1
Accession Number mRNA
NM_002424
Chromosomal Location
11q22.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-8
Clone
(#7A11)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: Use at 1:400-1000; IHC: 1:50-200
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

Related Products

CatalogName
100-398-L500MMP-3
100-398-L250MMP-3
100-398-L100MMP-3
100-398-L50MMP-3
100-372-L100MMP-2
100-419-L500MMP-1
100-419-L250MMP-1
101-M118MMP-25
101-M110MMP-3
101-M116MMP-14

Alternative Products

CatalogName
QY-E05364Human Quantikine MMP-8 (MMP-8)
525434-01MMP-8
20R-1626MMP 8 antibody
539072-01MMP-8 discontinued
EK0464h.MMP-8
MBS9401537-01MMP-8 Antibody
OPPA00821-1IUMMP 8 Protein
TRC-M425440-50MGMMP 8-I
B2014149MMP 8 Substrate
MBS5823429MMP-9-IN-8

Popular Products