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MMP-7

CAT: 0209-101-M111Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M111Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of the extracellular matrix including collagen IV and X, gelatin, casein, laminin, aggrecan, entactin, elastin and versican. MMP7 is implicated in the activation of other proteinases such as plasminogen, MMP1, MMP2, and MMP9. In addition to its roles in connective tissue remodeling and cancer, MMP7 also regulates intestinal α-defensin activation in innate host defense, releases tumor necrosis factorα in a model of herniated disc resorption, and cleaves FasL to generate a soluble form in a model of prostate involution. Structurally, MMP7 is the smallest of the MMPs and consists of two domains: a prodomain that is cleaved upon activation and a catalytic domain containing the zincbinding site.
Synonyms
MMP7; MMP-7; MPSL1; PUMP-1
NCBI Gene ID
4316
UniProt
P09237
Accession Number
NP_002414.1
Accession Number mRNA
NM_002423.3
Chromosomal Location
11q22.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-7
Clone
(#4C21)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: Use at 1:200-2000; IHC: 1:50-200
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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