MIP-5 (CCL15)

• Description:

  MIP-5 is a CC chemokine that is expressed in the heart, skeletal muscle and adrenal gland. MIP-5 primarily signals through he CCR1 receptor, but also has been found to bind to CCR3. MIP-5 is chemotactic towards T cells and monocytes. Recombinant human MIP-5 is a 10.1 kDa protein containing 92 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL15; LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; SCYL3; MIP-1D; MRP-2B; SCYA15; HMRP-2B

• NCBI Gene ID:

  6359

• UniProt:

  Q16663

• Accession Number:

  NP_116741.1

• Accession Number mRNA:

  NM_032965

• Chromosomal Location:

  17q11.2

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human

• Sequence:

  QFTNDAETEL MMSKLPLENP VVLNSFHFAA DCCTSYISQS IPCSLMKSYF ETSSECSKPG VIFLTKKGRQ VCAKPSGPGV QDCMKKLKPY SI

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human T lymphocytes using a concentration range of 1.0-10.0 ng/ml.

• Length:

  92

• Form:

  Lyophilized

• Molecular Weight:

  10.1 kDa

• Host or Source:

  E. coli