MIP-3 alpha (CCL20)

• Description :

  MIP-3 alpha is a CC chemokine that is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 alpha is an 8.0 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms :

  CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; MIP-3-alpha

• NCBI Gene ID :

  6363

• UniProt :

  P78556

• Accession Number :

  NP_004582.1

• Accession Number mRNA :

  NM_004591

• Chromosomal Location :

  9p13

• Reactivity :

  Human

• Cross Reactivity :

  Mouse, Rat, Human

• Sequence :

  ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml.

• Length :

  70

• Form :

  Lyophilized

• Molecular Weight :

  8.0 kDa

• Host or Source :

  E. coli