MIP-3 (CCL23)

• Description :

  MIP-3 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 is an 11.3 kDa protein containing 99 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms :

  CCL23; CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; CK-BETA-8

• NCBI Gene ID :

  6368

• UniProt :

  P55773

• Accession Number :

  NP_005055

• Accession Number mRNA :

  NM_005064

• Chromosomal Location :

  17q12

• Reactivity :

  Human

• Cross Reactivity :

  Human, Mouse

• Sequence :

  RVT kDaETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR SIPCSLLESY FETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL DTRIKTRKN

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human T cell population using a concentration of 10-50 ng/ml.

• Length :

  99

• Form :

  Lyophilized

• Molecular Weight :

  11 kDa

• Host or Source :

  E. coli