MIP-1 beta (CCL4)

CAT: 0209-R20-035SSize: 5 µgDry Ice: NoHazardous: No
CAT#:0209-R20-035SSize:5 µg
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Description
Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Synonyms
Ccl4; Scya4; Mip1-b
NCBI Gene ID
116637
UniProt
P50230
Accession Number
NP_446310
Accession Number mRNA
NM_053858
Chromosomal Location
10q26
Reactivity
Rat
Cross Reactivity
Human, Rat
Sequence
APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 µg/ml.
Length
69
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli

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