Products for Research Use Only
RegisterLogin

MCPT-6

CAT: 0209-103-M547Size: 50 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-103-M547Size:50 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tryptases are trypsin-like serine proteases, and beta tryptases appear to be the main isoenzymes expressed in mast cells. Mast cell protease-6 (MCP-6, MCPT6, or Tpsb2) is one of beta tryptases produced from mouse mast cells. It is stored in secretory granules of mast cells, where it forms active tetramers with heparin proteoglycan. Because of the unique arrangement of the active sites in the tetramer, which are facing a narrow central pore, Mcpt6 is resistant to macromolecular protease inhibitors. When mast cells are activated, Mcpt6 is released along with other proteins in secretory granules, participating in provoking inflammatory conditions. Mcpt6 has been implicated as a mediator in the pathogenesis of asthma and other allergic disorders in mouse models.
Synonyms
Tryptase beta-2, Tryptase-2, Mast cell protease 6 (mMCP-6)
NCBI Gene ID
17229
UniProt
P21845
Accession Number
NP_034911.3
Accession Number mRNA
NM_010781.3
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse MCPT-6
Clone
(#14F4)
Applications
IP, N/B
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

UniProtKB · P21845

Tryptase beta-2

TRYB2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P21845
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Tpsb2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
Tryptase-2
EC number
3.4.21.59
Processing
Precursor
Secondary accessions
Q61962
Protein keywords

Coding sequence diversity

Alternative splicing

Technical term

Direct protein sequencingReference proteome

PTM

Disulfide bondGlycoproteinPhosphoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

Related Products

CatalogName
R20-008-L50IL-6
200-031-L100IL-6
100-378-L250BMP-6
100-378-L100BMP-6
101-M411FGF-6
M10-017IL-6
100-019SFGF-6
100-378BMP-6
200-031IL-6
R20-008IL-6

Alternative Products

CatalogName
MBS692658-01MCPT-6
GTR18089800Rat Monoclonal mouse MCPT-6 Antibody
299189MCPT-6 (Mast Cell Protease-6, beta-Chymase)
mAP-0470Rat Monoclonal anti-mouse MCPT-6
TRC-H355020-2.5MG4-Hydroxy McPT Hydrochloride
YP-W24032-01Mouse Mast cell protease6 (Mcpt-6) ELISA Kit
E110580Mouse Mcpt-1 ELISA Kit
mAP-0469Rat Monoclonal anti-mouse MCPT-1
GA202611Mouse Mcpt-ps1 activation kit by CRISPRa
GTR18187643-01Rat Monoclonal mouse MCPT-1 Antibody

Popular Products