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MCPT-6

CAT: 0209-103-M547Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M547Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tryptases are trypsin-like serine proteases, and beta tryptases appear to be the main isoenzymes expressed in mast cells. Mast cell protease-6 (MCP-6, MCPT6, or Tpsb2) is one of beta tryptases produced from mouse mast cells. It is stored in secretory granules of mast cells, where it forms active tetramers with heparin proteoglycan. Because of the unique arrangement of the active sites in the tetramer, which are facing a narrow central pore, Mcpt6 is resistant to macromolecular protease inhibitors. When mast cells are activated, Mcpt6 is released along with other proteins in secretory granules, participating in provoking inflammatory conditions. Mcpt6 has been implicated as a mediator in the pathogenesis of asthma and other allergic disorders in mouse models.
Synonyms
Tryptase beta-2, Tryptase-2, Mast cell protease 6 (mMCP-6)
NCBI Gene ID
17229
UniProt
P21845
Accession Number
NP_034911.3
Accession Number mRNA
NM_010781.3
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse MCPT-6
Clone
(#14F4)
Applications
IP, N/B
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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