MCP-1

• Description:

  Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein-1 (MCP-1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1) . The gene span is 1,927 bases and the CCL2 gene resides on the Watson (plus) strand. The CCL2 gene has three exons and two introns. The CCL2 [protein precursor]] contains a signal peptide of 23 amino acids. In turn, the mature CCL2 is 76 amino acids long. The CCL2 predicted weight is 11.025 kDa.

• Synonyms:

  CCL2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30

• NCBI Gene ID:

  6347

• UniProt:

  P13500

• Accession Number:

  NP_002973

• Accession Number mRNA:

  NM_002982

• Chromosomal Location:

  17q11.2-q12

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant Human MCP-1

• Applications:

  ELISA, WB, IHC (P)

• Purification Method:

  Protein A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Form:

  Lyophilized from PBS

• Buffer:

  PBS

• Reconstitution:

  Water

• Storage Conditions:

  The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

• Host or Source:

  Mouse

• Isotype:

  IgG2a, kappa