LIX/CXCL6 (92 aa)

• Description:

  LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant murine LIX is a 9.8 kDa protein containing 93 amino acid residues.

• Synonyms:

  Cxcl5; LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II

• NCBI Gene ID:

  20311

• UniProt:

  P50228

• Accession Number:

  NP_033167.2

• Accession Number mRNA:

  NM_009141.2

• Chromosomal Location:

  5 E1; 5 53.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse

• Sequence:

  APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SVQ

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.

• Length:

  93

• Form:

  Lyophilized

• Molecular Weight:

  9.8 kDa

• Host or Source:

  E. coli