GCP-2 (CXCL6)

• Description:

  GCP-2 is a connective tissue derived CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. GCP-2 selectively attracts neutrophils and has also been shown to exert anti-angiogenic activity. Human GCP-2 is cross-react on murine cells. Recombinant human GCP-2 is a 7.9 kDa protein containing 72 amino acid residues.

• Synonyms:

  CXCL6; GCP2; CKA-3; GCP-2; SCYB6

• NCBI Gene ID:

  6372

• UniProt:

  P80163

• Accession Number:

  NP_002984.2

• Accession Number mRNA:

  NM_002993.4

• Chromosomal Location:

  4q21

• Reactivity:

  Human

• Cross Reactivity:

  Hamster, Monkey, Rat, Human, Bacteria

• Sequence:

  VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-50.0 ng/ml.

• Length:

  72

• Form:

  Lyophilized

• Molecular Weight:

  7.9 kDa

• Host or Source:

  E. coli