Leptin Recombinant Protein
CAT:
209-100-061S
Size:
200 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Leptin Recombinant Protein
- Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues.
- Synonyms: LEP; OB; OBS
- CAS Number: 9000-83-3
- NCBI Gene ID: 3952
- UniProt: P41159
- Accession Number: NP_000221.1
- Accession Number mRNA: NM_000230
- Gene Location: 7q31.1
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Chicken, Monkey, Mouse, Rat, Human
- Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC
- Detection Range: Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 147
- Form: Lyophilized
- Molecular Weight: 16 kDa
- Shipping Conditions: Room Temperature