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Junctional adhesion molecule C (JAM-C)

CAT: 0209-101-M526Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M526Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.
Synonyms
JAM3; JAMC; JAM-C
NCBI Gene ID
83700
UniProt
Q9BX67
Accession Number
NP_116190.3
Accession Number mRNA
NM_032801
Chromosomal Location
11q25
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human JAM-C
Clone
(#4M35)
Applications
WB, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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Alternative Products

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216750JAM-A (Junctional Adhesion Molecule A)
216753JAM-C (Junctional Adhesion Molecule C)
J8025Junctional Adhesion Molecule C (JAM-C)
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MBS6269708-01JAM-C (Junctional Adhesion Molecule C, JAM-2, Junctional Adhesion Molecule 3, JAM-3) (HRP)
MBS6269707-01JAM-C (Junctional Adhesion Molecule C, JAM-2, Junctional Adhesion Molecule 3, JAM-3) (FITC)
MBS6269704-01JAM-C (Junctional Adhesion Molecule C, JAM-2, Junctional Adhesion Molecule 3, JAM-3) (AP)
MBS6269706-01JAM-C (Junctional Adhesion Molecule C, JAM-2, Junctional Adhesion Molecule 3, JAM-3) (Biotin)
MBS6269705-01JAM-C (Junctional Adhesion Molecule C, JAM-2, Junctional Adhesion Molecule 3, JAM-3) (APC)

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