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Indian Hedgehog N-terminus

CAT: 0209-103-M286Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M286Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Indian Hedgehog (Ihh), Sonic Hedgehog (Shh), and Desert Hedgehog (Dhh) are important signaling molecules during embryonic development and are highly conserved within and across species. Mouse Ihh cDNA encodes a 411 amino acid (aa) polypeptide with a predicted 27 aa signal peptide. Post-translational processing yields a 19 kDa lipid-modified N-terminal domain that is the signaling molecule. At the cell surface, Ihh activity is mediated by binding the 12-pass transmembrane receptor, Patched (Ptc), and signaling through the 7-pass transmembrane G-protein coupled receptor, Smoothened (Smo) .
Synonyms
IHH; BDA1; HHG2
NCBI Gene ID
16147
UniProt
P97812
Accession Number
NP_034674.1
Accession Number mRNA
NM_010544.2
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant protein of N-Terminal fragment of ihh protein
Clone
(#3A11)
Applications
WB
Purification Method
Protein A/G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

UniProtKB · P97812

Indian hedgehog protein

IHH_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P97812
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Ihh
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
IHH
EC number
3.1.-.-
Processing
Precursor
Secondary accessions
Q61724
Protein keywords

PTM

Autocatalytic cleavageGlycoproteinLipoproteinPalmitate

Ligand

CalciumMetal-bindingZinc

Cellular component

Cell membraneEndoplasmic reticulumGolgi apparatusMembraneSecreted

Molecular function

Developmental proteinHydrolaseProteaseTransferase

Technical term

Reference proteome

Domain

Signal

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M10-057-L100Sonic Hedgehog
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