IL-33

• Description:

  Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

• Synonyms:

  IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2

• NCBI Gene ID:

  90865

• UniProt:

  O95760

• Accession Number:

  NP_254274

• Accession Number mRNA:

  NM_033439

• Chromosomal Location:

  9p24.1

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human

• Sequence:

  SITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.

• Length:

  159

• Form:

  Lyophilized

• Molecular Weight:

  17.9 kDa

• Host or Source:

  E. coli