IL-31 Recombinant Protein
CAT:
209-100-232S
Size:
2 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IL-31 Recombinant Protein
- Description: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.
- Synonyms: IL31; IL-31
- CAS Number: 9000-83-3
- NCBI Gene ID: 386653
- UniProt: Q6EBC2
- Accession Number: NP_001014358.1
- Accession Number mRNA: NM_001014336.1
- Gene Location: 12q24.31
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Human
- Sequence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
- Detection Range: Measured by its ability to induce STAT3 activation in human U87 cells.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 141
- Form: Lyophilized
- Molecular Weight: 15.8 kDa
- Shipping Conditions: Room Temperature