IL-24

• Description:

  IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.

• Synonyms:

  Interleukin 24; C49A; FISP; MDA7; MOB5; ST16; IL10B

• NCBI Gene ID:

  11009

• UniProt:

  Q13007

• Accession Number:

  NP_006841.1

• Accession Number mRNA:

  NM_006850.3

• Chromosomal Location:

  1q32

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Label:

  His-tag

• Sequence:

  QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVLQNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA NNFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTKALG EVDILLTWMQ KFYKLHHHHH H

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Testing in progress.

• Length:

  161

• Form:

  Lyophilized

• Molecular Weight:

  18.9 kDa

• Host or Source:

  CHO cells