IL-17F

• Description:

  IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains.

• Synonyms:

  Cytokine ML-1; IL-17F; ILN; Interleukin; Interleukin-17F; interleukin-24; Interleukin17F; mutant IL-17F

• NCBI Gene ID:

  64806

• UniProt:

  Q96PD4

• Accession Number:

  NP_443104.1

• Accession Number mRNA:

  NM_052872.3

• Chromosomal Location:

  14q11.2

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to induce IL-6 production by NHDF cells.

• Length:

  133

• Form:

  Lyophilized

• Molecular Weight:

  30.1 kDa

• Host or Source:

  E. coli