Rat Anti-Mouse IL-17E Monoclonal Antibody

Rat Anti-Mouse IL-17E Monoclonal Antibody

• Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
• Synonyms: Il25; Il17e; IL-17e
• CAS Number: 9007-83-4
• NCBI Gene ID: 140806
• UniProt: Q8VHH8
• Accession Number: NP_2542767.1
• Accession Number mRNA: NM_080729.3
• Gene Location: 14 C3; 14
• Host: Rat
• Origin Species: Mouse
• Species Reactivity: Mouse
• Target Antigen: Mouse Recombinant protein of IL-17E
• Isotype: IgG2
• Clone: (#5J46)
• Validated Applications: WB
• Purification Method: Protein A/G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.