IL-17E

• Description:

  IL‐17E is a disulfide‐linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17E stimulates secretion of IL‐8, and induces activation of the transcription factor NF‐κB in cells that express the IL‐17BR receptor. Recombinant Murine IL‐17E is a 35.0 kDa disulfide‐linked homodimer of two 152-amino-acid polypeptide chains.

• Synonyms:

  Interleukin-17E

• NCBI Gene ID:

  140806

• UniProt:

  Q8VHH8

• Accession Number:

  NP_542767.1

• Accession Number mRNA:

  NM_080729.3

• Chromosomal Location:

  14, 14 C3

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  MLRIQEGCSH LPSCCPSKEQ EPPEEWLKWS SASVSPPEPL SHTHHAESCR ASKDGPLNSR AISPWSYELD RDLNRVPQDL YHARCLCPHC VSLQTGSHMD PLGNSVPLYH NQTVFYRRPC HGEEGTHRRY CLERRLYRVS LACVCVRPRV MA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  ≥ 98% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Measured by its ability to induce GROα (CXCL1) secretion in HT‑29 human colon adenocarcinoma cells.

• Length:

  152

• Form:

  Lyophilized

• Molecular Weight:

  35.0 kDa

• Host or Source:

  E.coli