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IL-17E

CAT: 0209-M10-235Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0209-M10-235Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL‐17E is a disulfide‐linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17E stimulates secretion of IL‐8, and induces activation of the transcription factor NF‐κB in cells that express the IL‐17BR receptor. Recombinant Murine IL‐17E is a 35.0 kDa disulfide‐linked homodimer of two 152-amino-acid polypeptide chains.
Synonyms
Interleukin-17E
NCBI Gene ID
140806
UniProt
Q8VHH8
Accession Number
NP_542767.1
Accession Number mRNA
NM_080729.3
Chromosomal Location
14, 14 C3
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
MLRIQEGCSH LPSCCPSKEQ EPPEEWLKWS SASVSPPEPL SHTHHAESCR ASKDGPLNSR AISPWSYELD RDLNRVPQDL YHARCLCPHC VSLQTGSHMD PLGNSVPLYH NQTVFYRRPC HGEEGTHRRY CLERRLYRVS LACVCVRPRV MA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Measured by its ability to induce GROα (CXCL1) secretion in HT‑29 human colon adenocarcinoma cells.
Length
152
Form
Lyophilized
Molecular Weight
35.0 kDa
Host or Source
E.coli

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