IL-17D

• Description:

  IL‐17D is a disulfide‐linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17D has the ability to stimulate the production of IL‐6, IL‐8 and GM‐CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony‐forming assays. Recombinant Murine IL-17D is a 40.6 kDa, disulfide-linked homodimer of two 183 amino acid, polypeptide chains.

• Synonyms:

  Interleukin-17D

• NCBI Gene ID:

  239114

• UniProt:

  Q8K4C4

• Accession Number:

  NP_665836.2

• Accession Number mRNA:

  NM_145837.3

• Chromosomal Location:

  14; 14 C3

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  AGALRTGRRP ARPRDCADRP EELLEQLYGR LAAGVLSAFH HTLQLGPREQ ARNASCPAGG RAADRRFRPP TNLRSVSPWA YRISYDPARF PRYLPEAYCL CRGCLTGLYG EEDFRFRSTP VFSPAVVLRR TAACAGGRSV YAEHYITIPV GCTCVPEPDK SADSANSSMD KLLLGPADRP AGR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  ≥ 95% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by its ability to bind murine IL-17RB Fc Chimera in a functional ELISA.

• Length:

  183

• Form:

  Lyophilized

• Molecular Weight:

  40.6 kDa

• Host or Source:

  E.coli