IL-17D

• Description:

  IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

• Synonyms:

  IL17D; IL27; IL-22; IL-27; IL-17D

• NCBI Gene ID:

  53342

• UniProt:

  Q8TDA2

• Accession Number:

  NP_612141.1

• Accession Number mRNA:

  NM_138284

• Chromosomal Location:

  13q12.11

• Reactivity:

  Human

• Cross Reactivity:

  Mouse

• Sequence:

  APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT LQLGPREQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR ISYDPARYPR YLPEAYCLCR GCLTGLFGEE DVRFRSAPVY MPTVVLRRTP ACAGGRSVYT EAYVTIPVGC TCVPEPE kDa DSINSSIDKQ GAKLLLGPND APAGP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Testing in progress.

• Length:

  185

• Form:

  Lyophilized

• Molecular Weight:

  40.5 kDa

• Host or Source:

  E. coli