Products for Research Use Only
RegisterLogin

IL-17A

CAT: 0209-100-055Size: 25 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-100-055Size:25 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimer. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
Synonyms
IL17A; IL17; CTLA8; IL-17; IL-17A
NCBI Gene ID
3605
UniProt
Q16552
Accession Number
NP_002181.1
Accession Number mRNA
NM_002190.2
Chromosomal Location
6p12
Reactivity
Human
Cross Reactivity
Mouse, Human, Cow
Sequence
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml. Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.
Length
136
Form
Lyophilized
Molecular Weight
31 kDa
Host or Source
E. coli

Related Products

CatalogName
100-161SIL-37 (IL-1F7)
100-161-L250IL-37 (IL-1F7)
101-M784IL-18 (IL-1F4)
100-161IL-37 (IL-1F7)
100-161-L500IL-37 (IL-1F7)
100-161-L1000IL-37 (IL-1F7)
100-161-L100IL-37 (IL-1F7)
100-092-L100IL-36 gamma (IL-1F9)
100-091-L500IL-36 beta (IL-1F8)
100-160-L1000IL-36 alpha (IL-1F6)

Alternative Products

CatalogName
397101IL-17A (Interleukin-17A)
MBS590052-01Interleukin-17A (IL-17A)
E21-D14Interleukin-17A/IL-17A
NBP2-29362-0.01gCelastrol, IL-17A (IL-17A Inhibitor)
MBS8532908-01IL-17A
cyt-250-01IL 17A
351839IL-17A (Interleukin-17A) (PE)
MBS8532839-01IL-17/IL-17A

Popular Products