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IL-10

CAT: 0209-M10-020Size: 10 μgDry Ice: NoHazardous: No
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CAT#:0209-M10-020Size:10 μg
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Description
Interleukin 10 (IL-10), initially designated cytokine synthesis inhibitory factor (CSIF), was originally identified as a product of mouse T helper (Th) 2 clones that inhibited cytokine production by Th1 clones . The human ortholog of mouse IL-10 was subsequently cloned by cross-hybridization. Human and mouse IL-10 are 81% identical at the nucleotide and amino acid level. IL-10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. A number of viruses, including Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV), also encode viral members of the IL-10 family. Human IL-10 has cross-species actvity and is active on mouse cells. Mouse IL-10 is species-specific and does not act on human cells.
Synonyms
Il10; CSIF; Il-10
NCBI Gene ID
16153
UniProt
P18893
Accession Number
NP_034678
Accession Number mRNA
NM_010548
Chromosomal Location
1 E4; 1 69.9 cM
Reactivity
Mouse
Cross Reactivity
Human, Rat, Mouse
Sequence
SRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The biologically activity was measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be < 2 ng/ml (> 5 x 105 units/mg) .
Length
160
Form
Lyophilized
Buffer
5 mM Tris, pH 8.0
Molecular Weight
18.8 kDa
Host or Source
E. coli

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