IL-9

• Description:

  IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant murine IL-9 is a 14.3 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.

• Synonyms:

  Il9; P40; Il-9

• NCBI Gene ID:

  16198

• UniProt:

  P15247

• Accession Number:

  NP_032399.1

• Accession Number mRNA:

  NM_008373

• Chromosomal Location:

  13 B1; 13 35.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse

• Sequence:

  MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent proliferation of human MO7e cells is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.

• Length:

  127

• Form:

  Lyophilized

• Molecular Weight:

  14.3 kDa

• Host or Source:

  E. coli