IL-7

• Description:

  IL-7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and murine IL-7 is cross-species reactive. Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.

• Synonyms:

  IL7; IL-7

• NCBI Gene ID:

  3574

• UniProt:

  P13232

• Accession Number:

  NP_000871.1

• Accession Number mRNA:

  NM_000880

• Chromosomal Location:

  8q12-q13

• Reactivity:

  Human

• Cross Reactivity:

  Monkey, Mouse, Rat, Human, Leech

• Sequence:

  MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

• Length:

  153

• Form:

  Lyophilized

• Buffer:

  10 mM Acetic Acid

• Molecular Weight:

  17.4 kDa

• Host or Source:

  E. coli